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Can Microbiome Cause Autism, ADHD or Epilepsy?

To answer this question, it is essential to have a deep knowledge of human physiology. The human body is a complex system governed by a series of coordinated biological and biochemical processes that allow for its proper functioning. From hormonal regulation to immune response, each part of the body serves a specific function that contributes to the maintenance of health and overall well-being. Although the complete understanding of all these processes is a constant challenge, it is fundamental to have a knowledge for treatment of diseases.

Autism spectrum disorder (ASD) is a complex developmental condition involving persistent challenges with social communication, restricted interests and repetitive behavior. Epilepsy is a brain disorder characterized by a tendency to experience repeated unprovoked seizures. These seizures result from abnormal and sudden changes in neuronal electrical activity due to an imbalance in the brain’s excitatory and inhibitory networks. ADHD stands for attention deficit hyperactivity disorder. It is a medical condition. A person with ADHD has differences in brain development and brain activity that affect attention, the ability to sit still, and self-control.

The diversity and dysregulation of intestinal microbiota is related to the pathology of Autism, ADHD and Epilepsy acording to the evidence. The relationship between altered gut microbiota and conditions such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and epilepsy has been suggested by recent research. Findings show differences in microbiota richness and abundance of certain bacteria between affected children and healthy controls. Additionally, a subset of children with ADHD and ASD exhibited higher levels of LBP, a marker of intestinal barrier disruption, and increased levels of certain interleukins, indicating immune dysregulation. This article examines the gut microbiota composition in children with these disorders and explores the potential systemic effects of these bacteria.

In recent times, researchers have shown increasing interest in gut microbiota. The brain-gut axis, which refers to the two-way communication system between the brain and the gut, includes gut microbiota as a crucial component. Studies have found notable variations in the levels of certain bacteria in patients with focal epilepsy, such as Faecalibacterium, Collinsella, Escherichia/Shigella, Streptococcus, and Megamonas. Furthermore, significant disparities were observed in the microbial composition before and after treatment, with the gut microbiota of individuals who responded well to treatment resembling that of healthy children. This suggests that the effectiveness of treatment may be linked to changes in gut microbiota. Following successful monotherapy, the differences decreased and there was an enhancement in carbohydrate metabolism within the gut microbiota.

To conclude there is enough evidence that the impact of a diversed microbiome is beneficial in the this three clinical conditions. The composition and variety of gut bacteria were found to vary between infants experiencing different symptoms of epilepsy. Healthy infants and those with epilepsy and diarrhea both showed a prevalence of Bifidobacterium and Escherichia/Shigella in their intestinal microbiota. The network of relationships among bacteria was found to be more complex and tightly connected in healthy infants compared to those with epilepsy. In infants with epilepsy, there was a high level of connectivity within specific bacterial communities but less interaction between different communities. Infants with epilepsy and diarrhea had a more concentrated network of localized connections among their gut bacteria. The relationship between the gut microbiome and its host is maintained through various mechanisms such as neurological, hormonal, and immune pathways, forming the microbiome-gut-brain axis. Changes in this axis are linked to the development of neurological and neurodevelopmental disorders in children. In individuals with ADHD, the microbiome-gut-brain axis plays a role in causing neuroinflammation and oxidative stress, leading to ADHD symptoms and related conditions like sleep disorders. The composition of the gut microbiome may also play aThe complex interplay between the gut microbiota and autism spectrum disorder , let us fully understand and harness the potential benefits of microbiota-based interventions for children with ASD. Standardized protocols, larger sample sizes, and controlled studies are necessary to validate and build upon the findings presented in this review. The dynamic nature of the gut microbiome and its impact on physiological and neurological processes emphasize the need for continued exploration in this evolving field.

A diet that is rich in fiber from whole foods is not only important for providing essential nutrients, but also for supporting a healthy gut microbiome. Plant-based foods are key for promoting microbiome diversity, especially those that are prebiotic like Jerusalem artichoke, onions, and garlic, as well as probiotic foods like sauerkraut and kimchi. Including a variety of fruits such as apples, berries, cherries, grapefruits, kiwi, nectarine, orange, and rhubarb can also help support a well-balanced microbiome.

My thoughts:

Recovery of the human microbiome post-antibiotics is slow and incomplete. Probiotics recommendations from an expert can help prevent negative impacts on the gut microbiome. Understanding how our body interacts with nutrients is crucial for overall health. The human body is designed in such a wonderful way that it has its own mechanisms to heal itself. Medicine should not be used as a lifestyle choice.

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